Next Generation

Immunotherapeutics

Apogenix develops innovative immunotherapeutics for the treatment of cancer and viral infections, such as COVID-19. The company has built a promising pipeline of drug candidates that target different TNFSF-dependent signaling pathways, thereby reducing lymphopenia and inflammatory cell death in patients with viral infections and restoring the anti-tumor immune response in cancer patients.

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Asunercept

Clinical Development in Three Indications

Our lead immunotherapy candidate asunercept is in clinical development for the treatment of solid tumors, malignant hematological diseases, and COVID-19. It has shown significant improvements in progression-free survival and quality of life as well as a positive trend in overall survival in a controlled phase II proof-of-concept trial in recurrent glioblastoma. In a phase I trial in myelodysplastic syndromes (MDS), treatment with asunercept led to a decrease in transfusion frequency in 40 percent of patients during the duration of the trial.

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Technology

The Apogenix team has created the HERA-ligand technology platform for the development of novel receptor agonists that target different TNFSF-dependent signaling pathways, which play a crucial role in the regulation of the immune response. These fusion proteins offer clear advantages over other biologics such as antibodies and have the potential for broad application in oncology.

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News

December 14, 2022
Apogenix’ Enrolls First Patients in Pivotal Phase III Trial for the Treatment of Hospitalized COVID-19 Patients with Asunercept

October 19, 2022
Apogenix’ Asunercept Demonstrates Efficacy in Phase II Trial for the Treatment of Hospitalized COVID-19 Patients


 



 

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