Next Generation

Immunotherapeutics

Apogenix develops innovative immunotherapeutics for the treatment of cancer and viral infections, such as COVID-19. The company has built a promising pipeline of drug candidates that target different TNFSF-dependent signaling pathways, thereby restoring the anti-tumor immune response in cancer patients and reducing lymphopenia and inflammatory cell death in patients with viral infections.

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Asunercept

Clinical Development in Three Indications

Our lead immuno-oncology candidate asunercept is in clinical development for the treatment of solid tumors, malignant hematological diseases, and COVID-19. It has shown significant improvements in progression-free survival and quality of life as well as a positive trend in overall survival in a controlled phase II proof-of-concept trial in recurrent glioblastoma. In a phase I trial in myelodysplastic syndromes (MDS), treatment with asunercept led to a decrease in transfusion frequency in 40 percent of patients during the duration of the trial.

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Technology

The Apogenix team has created the HERA-ligand technology platform for the development of novel receptor agonists that target different TNFSF-dependent signaling pathways, which play a crucial role in the regulation of the immune response. These fusion proteins offer clear advantages over other biologics such as antibodies and have the potential for broad application in oncology.

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News

May 13, 2020
Abstract “Explorative Analysis of Expanded Access for Intermediate-Size and Larger Patient Populations” accepted for publication by ASCO 2020

April 21, 2020
Corona: Apogenix to Start Clinical Trials with Asunercept (Rhein-Neckar-Zeitung news article, April 21, 2020)

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