Apogenix focuses on the development of immunotherapy drug candidates for the treatment of cancer and viral infections.
Our pipeline comprises several TNFRSF modulators that have the potential for broad application in the treatment of solid tumors, malignant hematological diseases, and viral infections, such as COVID-19.
Asunercept, a CD95 ligand inhibitor, is currently in clinical development for the treatment of cancer and viral infections.
Apogenix has also developed a proprietary single-chain ligand technology platform for the construction of novel TNFRSF agonists for the treatment of cancer. Preclinical experiments have shown that these agonists effectively stimulate the immune system and exhibit potent anti-tumor efficacy in different model systems, thus making them promising candidates for the treatment of solid tumors.
The excellent anti-tumor efficacy of Apogenix’ TRAIL receptor agonists has been demonstrated in a large number of preclinical studies. Apogenix has entered into a licensing agreement with AbbVie. In Q4 2021, AbbVie initiated a clinical phase Ib study with ABBV-621 (eftozanermin-alpha) in patients suffering from multiple myeloma.