Apogenix focuses on the development of immunotherapy drug candidates for the treatment of cancer and viral infections.
Our pipeline comprises several drug candidates that have the potential for broad application in the treatment of solid tumors, malignant hematological diseases, and viral infections, such as COVID-19.
Asunercept, a CD95 ligand inhibitor, is currently in clinical development for the treatment of glioblastoma, myelodysplastic syndromes, and COVID-19. Preclinical studies in a variety of tumor indications highlight the potential of asunercept in other solid tumors and malignant hematological diseases.
Apogenix has also developed the proprietary HERA-ligand technology platform for the construction of novel TNFSF receptor agonists for the treatment of cancer. Preclinical experiments have shown that these agonists effectively stimulate the immune system and exhibit potent anti-tumor efficacy in different model systems, thus making them promising candidates for the treatment of solid tumors.
The excellent anti-tumor efficacy of Apogenix’ TRAIL receptor agonists has been demonstrated in a large number of preclinical studies. Apogenix has entered into a licensing agreement with AbbVie in 2014. In March 2017, AbbVie initiated a clinical phase I study with ABBV-621 in patients suffering from solid tumors, non-Hodgkin's lymphoma (NHL) or acute myeloid leukemia (AML).